Lactic acidosis occurring during phenformin therapy
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چکیده
منابع مشابه
Lactic acidosis occurring during phenformin therapy.
Case history The patient was a 47-year-old woman who developed diabetes mellitus in 1965. She was initially controlled on chlorpropamide and phenformin. However, her diabetic control became less satisfactory and insulin therapy was substituted in October 1967. Subsequently her diabetes became unstable and phenformin 100-150 mg daily was added in November 1968. Since then her blood glucose level...
متن کاملPhenformin and lactic acidosis.
Thirty-eight patients who presented with diabetes and a changed state of consciousness satisfied the criteria for lactic acidosis. Sixteen patients were non-ketotic, and 15 of these were receiving phenformin on admission. In all but one of these 15 patients, however, additional renal or cardiovascular abnormalities, or both, could be identified, which supported a multifactorial aetiology for la...
متن کاملPhenformin-induced lactic acidosis in an older diabetic patient: a recurrent drama (phenformin and lactic acidosis).
sociated with albuminuria in type 2 diabetic patients (4). To the best of our knowledge, however, it is not clear whether serum homocysteine is associated with TNF receptor in type 2 diabetic patients. The aim of the present study was therefore to investigate the relationships between serum homocysteine and TNF receptor in patients with type 2 diabetes. Fifty nonobese Japanese type 2 diabetic p...
متن کاملLactic acidosis and hyperamylasaemia associated with phenformin therapy.
Introduction Lactic acidosis, first described by Clausen (1925), is most frequently seen accompanying hypotension and impaired tissue perfusion, but has been reported in association with many other conditions such as phenformin therapy, non-ketotic diabetic acidosis, ethanol ingestion and glycogen storage disease (Oliva, 1970; Lancet, 1973). Recently, an association was suggested between non-ke...
متن کاملFatal lactic acidosis after an overdose of phenformin.
The patient; a 64-year-old housewife, had been known to suffer from maturity-onset diabetes for four years. She was treated with chlorpropamide for 18 months, and then with a 1,000-calorie diet (130 g. of carbohydrate) alone for three months. She remained more than a stone (6.4 kg.) above the standard weight for her height and was therefore started on phenformin in May 1964 in order to treat he...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1972
ISSN: 0032-5473
DOI: 10.1136/pgmj.48.560.386